Meeting Summary for 9/15/08

Ina discussed how we can apply hypothesis testing to the gene expression data from microarrays. We got to know difference in Z-statistic formula when applied to observations directly versus the mean of observations (which follows the Normal Distribution according to the Central Limit theorem). The rest of the chapter on Hypothesis Testing will be studied individually and an overview of tests will be discussed on Wednesday, when they are applied, how they are applied and differences between tests conducted in same scenarios.

References :
1. X. Cui, G. A. Churchill, "Statistical tests for differential expression in cDNA microarray experiments", (Review), Genome Biology 2003, 4:210.
2. J. A. C. Sterne, G. D. Smith, "Sifting the evidence - what's wrong with significance tests?", (Education and Debate)BMJ, 27 January 2001, Volume 322.